{"id":3874,"date":"2023-01-18T17:10:09","date_gmt":"2023-01-18T17:10:09","guid":{"rendered":"https:\/\/www.institutofertilidadviamed.com\/clinica-alxen\/clinical-cases\/advanced-maternal-age\/"},"modified":"2023-02-21T10:26:24","modified_gmt":"2023-02-21T10:26:24","slug":"advanced-maternal-age","status":"publish","type":"page","link":"https:\/\/www.institutofertilidadviamed.com\/clinica-alxen\/en\/clinical-cases\/advanced-maternal-age\/","title":{"rendered":"Advanced maternal age"},"content":{"rendered":"\t\t
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Advanced maternal age<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Since the end of the 20th century and during the 21st century, two reproductive trends have become evident in the Western world. On the one hand, there is a propensity towards having fewer and fewer children, and on the other, to postpone motherhood to an ever-increasing age.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\tThe fact that fertility declines as women age is due to several factors. Firstly, female germ cells do not replicate during adult life, and the number of oocytes available (ovarian reserve) gradually depletes from birth.<\/strong>\n\nSecondly, the quality of these oocytes decreases with age, mainly due to an increase in the rate of aneuploidy in the oocyte.<\/strong> This higher rate of aneuploidy is chiefly due to an increase in the frequency of errors committed by agents involved in the regulation of the meiotic spindle assembly. The increase in chromosomal abnormalities within the oocyte leads to a higher rate of miscarriage and a higher risk of chromosomopathies in the foetus. Figure 7<\/em><\/a><\/span><\/strong> graphically depicts the decline in fertility and the increase in the miscarriage rate as the age of the woman increases. Both rates vary exponentially, so fertility loss is especially critical from a mean maternal age of 37 years onwards.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Figure. Changes in fertility rate (represented by the number of fertile women per 1000 married women) and in the rate of miscarriage based on maternal age. Adapted from Heffner et al.<\/em>, 2004 (Heffner, 2004). Reproduced with permission from the New England Journal of Medicine<\/em> (copyright Massachusetts Medical Society<\/em>).<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\tIn addition to the increase in aneuploidy, advanced maternal age is associated with increased oxidative metabolism in the oocyte and a poorer functioning of the antioxidant molecular mechanisms<\/strong>, leading to different morphological alterations of the oocyte and inadequate maturation of the oocyte cytoplasm.\n\nFinally, advanced age is associated with the appearance of other pathologies also related to infertility<\/strong>, such as uterine fibroids, endometriosis, or tubal pathologies.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\tThe treatment of advanced age patients combines the treatment of low ovarian reserve (more frequent among older women) with the best embryo selection to avoid the use of embryos with chromosomal alterations that make up majority at these ages; among these embryonic selection techniques, pre-implantation genetic testing of aneuploidy (PGT-A) can be carried out by means of embryo biopsy or by novel non-invasive techniques that are not yet as widely validated. There are other embryo selection techniques available using Time-Labs incubators with artificial intelligence that help to classify embryos with greater possibilities of implantation because they are more viable.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Advanced maternal age Since the end of the 20th century and during the 21st century, two reproductive trends have become evident in the Western world. On the one hand, there is a propensity towards having fewer and fewer children, and on the other, to postpone motherhood to an ever-increasing age. The fact that fertility declines […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":3807,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-3874","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nAdvanced maternal age - Instituto de fertilidad Viamed - IFV<\/title>\n<meta name=\"description\" content=\"Advanced maternal age is associated with increased oxidative metabolism in the oocyte and a poorer functioning of the antioxidant molecular mechanisms.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.institutofertilidadviamed.com\/clinica-alxen\/en\/clinical-cases\/advanced-maternal-age\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Advanced maternal age - 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