{"id":3883,"date":"2022-12-05T10:37:51","date_gmt":"2022-12-05T10:37:51","guid":{"rendered":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/sperm-dna-fragmentation-test\/"},"modified":"2026-07-13T10:43:27","modified_gmt":"2026-07-13T10:43:27","slug":"sperm-dna-fragmentation-test","status":"publish","type":"page","link":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/assisted-reproduction-techniques\/sperm-dna-fragmentation-test\/","title":{"rendered":"Sperm DNA fragmentation test in Seville"},"content":{"rendered":"\t\t
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Sperm DNA fragmentation test in Seville<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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At Viamed Fertility Institute, we know that few things generate as much frustration as receiving a diagnosis of \u201cunexplained infertility\u201d. Many couples often come to our consultation in Seville after months of unsuccessful attempts, despite having a semen analysis with apparently normal values. However, sperm count and motility are only the tip of the iceberg. <\/p>

The sperm DNA fragmentation test is the diagnostic tool that allows us to look beneath what cannot be seen with the naked eye: the integrity of the genetic material.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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What is DNA fragmentation and how does it affect fertility?<\/h2>

To understand this concept simply, imagine that the sperm\u2019s DNA is an instruction book that it must deliver to the egg in order to \u201cbuild\u201d a baby. If that book arrives with torn, crossed-out or disordered pages, the embryo will not be able to read the instructions correctly. These breaks in the chain of genetic material are what we call fragmentation. <\/p>

Even if the sperm is able to reach the egg and fertilise it, if its DNA is damaged, embryo development may stop prematurely. For this reason, this test is essential for assessing the man\u2019s real fertility quality beyond the appearance or quantity of sperm cells. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Single-strand vs. double-strand fragmentation<\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tNot all \u201cbreaks\u201d in DNA have the same consequences. Thanks to the high-complexity hospital laboratory at our centre in Seville, we can differentiate between two types of fragmentation: \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSingle-strand fragmentation\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tThis reduces the egg\u2019s fertilisation potential and the spontaneous pregnancy rate, and is mainly associated with difficulties achieving pregnancy naturally or through low-complexity techniques. However, it may improve with antioxidant therapy over 2 to 3 months, and the oocyte has the ability to repair this damage. \t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDouble-strand fragmentation\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tThis increases the miscarriage rate, the rate of embryo development arrest and the rate of implantation failure in the uterus. As both DNA helices are damaged, this type of damage does not improve with antioxidants and the oocyte is usually unable to repair it. \t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\tTo overcome these obstacles, it is possible to select sperm with lower DNA fragmentation using sperm selection techniques such as Zymot and MACS. In addition, depending on the case, genetic diagnostic techniques such as PGT may be recommended to rule out embryos with genetic abnormalities caused by this sperm DNA fragmentation. \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Why is a conventional semen analysis not always enough?<\/h2>

A basic semen analysis is a fundamental test, but it has limitations. It analyses the sperm\u2019s \u201clogistics\u201d: how many there are, how they move and what shape they have. It is like checking that an envelope is properly sealed and has the correct address. <\/p>

However, the sperm DNA fragmentation test analyses the contents of the envelope: the genetic message. A man may have an excellent sperm count and enviable motility, but if the DNA they carry is fragmented, the chances of success decrease dramatically. That is why, in Seville, we recommend this test to obtain a 360-degree view of the man\u2019s reproductive capacity. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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The safety of carrying out the study at Viamed Hospital Santa \u00c1ngela de la Cruz<\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tPerforming this test in a high-complexity hospital environment offers a level of precision that not all centres can guarantee. At Viamed Fertility Institute, we do not use manual or subjective readings that depend on the technician\u2019s eye. \n\nWe use flow cytometry, an automated technology that analyses thousands of sperm cells in seconds using laser technology. This technique allows us to provide: \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tObjective results\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tWe eliminate human error in interpretation. \t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\tAs we have our own laboratory within the hospital, waiting times are reduced.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tReliability\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\t We work under the rigorous quality standards of Viamed Salud, ensuring that every data point is accurate when planning your treatment.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Who is this test recommended for?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tOur team of professionals usually recommends the fragmentation study in the following cases: \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tUnexplained infertility\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tWhen basic tests do not reveal why pregnancy is not occurring.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRecurrent miscarriage\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tEspecially to detect double-strand fragmentation.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tImplantation failure\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tAfter IVF cycles in which the embryos appeared to be of good quality but did not implant.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMen over 45\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tAge directly influences the accumulation of damage in sperm DNA.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tExternal factors\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tMen who smoke, have obesity or have been exposed to high temperatures or environmental toxins.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVaricocele\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tA common medical cause of fragmentation that should be assessed. \t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Solutions after diagnosis: advanced sperm selection<\/h2>

Receiving a result showing high fragmentation does not mean that the dream of becoming parents is over. Quite the opposite: it gives us the key to choosing the right technique. <\/p>

If we detect high levels of genetic damage, at Viamed Fertility Institute we apply advanced selection techniques such as Zymot or MACS. These systems allow us to filter and select only those sperm cells with intact DNA for fertilisation, exponentially increasing the chances of an ongoing and healthy pregnancy. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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FAQs: frequently asked questions about the fragmentation test in Seville <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tCan DNA fragmentation improve with treatment?<\/a>\n\t\t\t\t\t<\/h3>\n\n\t\t\t\t\t

Yes. In many cases, after a period of treatment with specific antioxidants and lifestyle changes, such as stopping smoking, DNA quality may improve. Our medical team will assess whether the test needs to be repeated after a few months. <\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tIs it a painful test?<\/a>\n\t\t\t\t\t<\/h3>\n\n\t\t\t\t\t

Not at all. The process is identical to a semen analysis; only a semen sample obtained through masturbation is required, after an abstinence period of between 3 and 5 days. <\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tHow long do the results take at the hospital?<\/a>\n\t\t\t\t\t<\/h3>\n\n\t\t\t\t\t

Thanks to our hospital infrastructure in Seville, we usually have the detailed report available within a few days, allowing us to adjust your treatment protocol without unnecessary delays. <\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEnsure the quality of your Life Project\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tDo not leave your dream to chance. A precise diagnosis is the first step towards success. Request your appointment for the sperm DNA fragmentation test today and let our team of experts help you find the shortest path to your baby. \t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tBOOK AN ADVANCED DIAGNOSTIC APPOINTMENT<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Sperm DNA fragmentation test in Seville At Viamed Fertility Institute, we know that few things generate as much frustration as receiving a diagnosis of \u201cunexplained infertility\u201d. Many couples often come to our consultation in Seville after months of unsuccessful attempts, despite having a semen analysis with apparently normal values. However, sperm count and motility are […]<\/p>\n","protected":false},"author":1,"featured_media":3522,"parent":4074,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-3883","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\nSperm DNA fragmentation test in Seville<\/title>\n<meta name=\"description\" content=\"Analyses sperm DNA breaks and their impact on fertilisation, implantation and miscarriage, with diagnosis at IVF Sevilla.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/assisted-reproduction-techniques\/sperm-dna-fragmentation-test\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sperm DNA fragmentation test in Seville\" \/>\n<meta property=\"og:description\" content=\"Analyses sperm DNA breaks and their impact on fertilisation, implantation and miscarriage, with diagnosis at IVF Sevilla.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/assisted-reproduction-techniques\/sperm-dna-fragmentation-test\/\" \/>\n<meta property=\"og:site_name\" content=\"Instituto de Fertilidad Viamed - Cl\u00ednica de fertilidad en Sevilla\" \/>\n<meta property=\"article:modified_time\" content=\"2026-07-13T10:43:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/wp-content\/uploads\/2022\/12\/GettyImages-1189437659.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2022\" \/>\n\t<meta property=\"og:image:height\" content=\"1483\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/assisted-reproduction-techniques\\\/sperm-dna-fragmentation-test\\\/\",\"url\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/assisted-reproduction-techniques\\\/sperm-dna-fragmentation-test\\\/\",\"name\":\"Sperm DNA fragmentation test in Seville\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/assisted-reproduction-techniques\\\/sperm-dna-fragmentation-test\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/assisted-reproduction-techniques\\\/sperm-dna-fragmentation-test\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/wp-content\\\/uploads\\\/2022\\\/12\\\/GettyImages-1189437659.jpg\",\"datePublished\":\"2022-12-05T10:37:51+00:00\",\"dateModified\":\"2026-07-13T10:43:27+00:00\",\"description\":\"Analyses sperm DNA breaks and their impact on fertilisation, implantation and miscarriage, with diagnosis at IVF Sevilla.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/assisted-reproduction-techniques\\\/sperm-dna-fragmentation-test\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/assisted-reproduction-techniques\\\/sperm-dna-fragmentation-test\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/assisted-reproduction-techniques\\\/sperm-dna-fragmentation-test\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/wp-content\\\/uploads\\\/2022\\\/12\\\/GettyImages-1189437659.jpg\",\"contentUrl\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/wp-content\\\/uploads\\\/2022\\\/12\\\/GettyImages-1189437659.jpg\",\"width\":2022,\"height\":1483,\"caption\":\"Genetic Syndrome and Genetic Disorder, 3D illustration of science concept. 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