{"id":5393,"date":"2023-11-17T08:32:23","date_gmt":"2023-11-17T08:32:23","guid":{"rendered":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/assisted-reproduction-techniques\/oocyte-activation-by-calcium-ionophore\/"},"modified":"2026-07-13T09:35:42","modified_gmt":"2026-07-13T09:35:42","slug":"oocyte-activation-by-calcium-ionophore","status":"publish","type":"page","link":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/assisted-reproduction-techniques\/oocyte-activation-by-calcium-ionophore\/","title":{"rendered":"Assisted oocyte activation in Seville"},"content":{"rendered":"\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

Oocyte activation at IFV Sevilla<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

At IFV Sevilla, we know that few situations are as bewildering for a couple as being told that their eggs have not fertilised after an ICSI cycle. When sperm microinjection is performed, the union of the gametes is expected to mark the beginning of life. However, sometimes the egg simply does not \u201cwake up\u201d. <\/p>

Assisted oocyte activation is the technological response to this challenge, designed to provide the necessary stimulus when biology needs extra support.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t
<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Why don\u2019t my eggs fertilise after ICSI?<\/h2>

In natural fertilisation or conventional ICSI, the sperm is responsible for sending a chemical signal to the egg so that it becomes activated. This signal triggers a series of calcium oscillations inside the egg, acting as a biological \u201cswitch\u201d. Without this increase in calcium, the egg does not activate, does not divide and, therefore, no embryo is formed. <\/p>

In some cases, either due to sperm-related factors, such as the absence of certain proteins, or due to the nature of the egg itself, this switch does not turn on spontaneously. In reproductive medicine, this is known as activation failure. Thanks to assisted oocyte activation with calcium ionophore, we can intervene at that precise moment to generate the necessary signal. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Certified hospital quality<\/h2>

innovation and rigour at Hospital Santa \u00c1ngela de la Cruz<\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Performing such a specific technique as calcium ionophore requires a highly precise laboratory environment. As we are located within Viamed Hospital Santa \u00c1ngela de la Cruz, we offer comprehensive safety: <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\n\t\t\t\n\t\t\t\t\t\t
\n\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tExtreme laboratory control\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tOur embryologists have the technology required to handle culture media with absolute precision, which is vital for the success of this technique. \t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\n\t\t\t\n\t\t\t\t\t\t
\n\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t24-hour hospital safety\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tThe support of Viamed Salud ensures that every process is carried out under the strictest standards of medical quality and biological safety. \t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\n\t\t\t\n\t\t\t\t\t\t
\n\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPrivacy and rigour\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tWe understand the emotional burden following previous fertilisation failure. For this reason, we approach each case with the sensitivity and scientific depth it requires.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

How does assisted oocyte activation with calcium ionophore work?<\/h2>

The process is fascinating and takes place entirely in our laboratory after egg retrieval:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t
\"\"<\/figure>

Microinjection, or ICSI<\/h3>

First, we introduce the sperm into the egg following the standard procedure.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t
\"\"<\/figure>

The \u201cspark\u201d of life<\/h3>

Immediately afterwards, the eggs are exposed to a special culture medium enriched with calcium ionophore. <\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t
\"\"<\/figure>

Biological activation<\/h3>

This medium allows calcium to enter the egg, imitating the natural signal that the sperm should have sent. It is, quite literally, the egg\u2019s \u201cawakening\u201d. <\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t
\"\"<\/figure>

Embryo development<\/h3>

Once activated, the egg begins to divide normally, allowing the assisted reproduction treatment to continue its course towards embryo transfer.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

\n\t\t\t
\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t
<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t\t
<\/div>\n\t\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

Who is this treatment recommended for?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\n\t\t\t\n\t\t\t\t\t\t
\n\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPrevious fertilisation failure\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tCouples who have undergone an ICSI cycle in which no eggs, or only a very low percentage, were fertilised. \t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\n\t\t\t\n\t\t\t\t\t\t
\n\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSevere male factor infertility\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tWhen it is suspected that the sperm lacks the necessary protein, PLC-zeta, to activate the egg.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\n\t\t\t\n\t\t\t\t\t\t
\n\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPoor oocyte quality\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tCases in which the eggs show signs of maturity but do not respond to fertilisation. \t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t
<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Restoring hope in your Life Project<\/h2>

The use of calcium ionophore has represented a paradigm shift for many couples who believed they had reached the end of the road. This technique can significantly increase fertilisation rates, achieving good-quality embryos in cases that were previously considered to have a poor prognosis. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

FAQs: questions about oocyte activation in Seville <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\t\t

\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t Is calcium ionophore safe for my future baby?<\/a>\n\t\t\t\t\t<\/h3>\n\n\t\t\t\t\t

Yes. Scientific studies carried out to date confirm that the use of calcium activation media does not increase the risk of congenital abnormalities or problems in the baby\u2019s development. It is a safe and well-established technique in highly complex laboratories such as ours. <\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

\n\t\t\t\t\t

\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tWhy does the egg not activate naturally in my case?<\/a>\n\t\t\t\t\t<\/h3>\n\n\t\t\t\t\t

It may be due to multiple biological factors. Sometimes it is a specific molecular incompatibility or a deficiency in chemical signalling. What matters is that today we have the technology to \u201creplace\u201d that signal and allow life to move forward. <\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

\n\t\t\t\t\t

\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tDoes this technique guarantee that all eggs will fertilise?<\/a>\n\t\t\t\t\t<\/h3>\n\n\t\t\t\t\t

Although assisted oocyte activation dramatically improves success rates in patients with previous fertilisation failure, fertilisation also depends on other internal biological factors within the gametes. Nevertheless, it is currently the best available tool to overcome the obstacle of activation failure. <\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t\t
<\/div>\n\t\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\n\t\t\t\t\t\t
\n\t\t\t\t\n\t\t\t\t
\n\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYour future starts with a decision today\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tDo not let fertilisation failure stop your dream of building a family. If your previous treatment did not achieve the expected results, our team at Hospital Santa \u00c1ngela de la Cruz may hold the key to reactivating your dream. \t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t
\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tREQUEST AN APPOINTMENT WITH OUR TEAM OF PROFESSIONALS IN SEVILLE<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Oocyte activation at IFV Sevilla At IFV Sevilla, we know that few situations are as bewildering for a couple as being told that their eggs have not fertilised after an ICSI cycle. When sperm microinjection is performed, the union of the gametes is expected to mark the beginning of life. However, sometimes the egg simply […]<\/p>\n","protected":false},"author":1,"featured_media":3522,"parent":4074,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-5393","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\nAssisted oocyte activation in Seville - Viamed Fertility Institute<\/title>\n<meta name=\"description\" content=\"Sperm fragmentation testing is a complementary technique which gives us more diagnostic information about the fertile potential of the male partner.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/assisted-reproduction-techniques\/oocyte-activation-by-calcium-ionophore\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Assisted oocyte activation in Seville - Viamed Fertility Institute\" \/>\n<meta property=\"og:description\" content=\"Sperm fragmentation testing is a complementary technique which gives us more diagnostic information about the fertile potential of the male partner.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/assisted-reproduction-techniques\/oocyte-activation-by-calcium-ionophore\/\" \/>\n<meta property=\"og:site_name\" content=\"Instituto de Fertilidad Viamed - Cl\u00ednica de fertilidad en Sevilla\" \/>\n<meta property=\"article:modified_time\" content=\"2026-07-13T09:35:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/wp-content\/uploads\/2022\/12\/GettyImages-1189437659.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2022\" \/>\n\t<meta property=\"og:image:height\" content=\"1483\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/assisted-reproduction-techniques\\\/oocyte-activation-by-calcium-ionophore\\\/\",\"url\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/assisted-reproduction-techniques\\\/oocyte-activation-by-calcium-ionophore\\\/\",\"name\":\"Assisted oocyte activation in Seville - Viamed Fertility Institute\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/assisted-reproduction-techniques\\\/oocyte-activation-by-calcium-ionophore\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/assisted-reproduction-techniques\\\/oocyte-activation-by-calcium-ionophore\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/wp-content\\\/uploads\\\/2022\\\/12\\\/GettyImages-1189437659.jpg\",\"datePublished\":\"2023-11-17T08:32:23+00:00\",\"dateModified\":\"2026-07-13T09:35:42+00:00\",\"description\":\"Sperm fragmentation testing is a complementary technique which gives us more diagnostic information about the fertile potential of the male partner.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/assisted-reproduction-techniques\\\/oocyte-activation-by-calcium-ionophore\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/assisted-reproduction-techniques\\\/oocyte-activation-by-calcium-ionophore\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/assisted-reproduction-techniques\\\/oocyte-activation-by-calcium-ionophore\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/wp-content\\\/uploads\\\/2022\\\/12\\\/GettyImages-1189437659.jpg\",\"contentUrl\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/wp-content\\\/uploads\\\/2022\\\/12\\\/GettyImages-1189437659.jpg\",\"width\":2022,\"height\":1483,\"caption\":\"Genetic Syndrome and Genetic Disorder, 3D illustration of science concept. Colorful DNA molecule.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/assisted-reproduction-techniques\\\/oocyte-activation-by-calcium-ionophore\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Assisted reproduction techniques\",\"item\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/tecnicas-fertilidad\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Assisted oocyte activation in Seville\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/\",\"name\":\"Instituto de fertilidad Viamed\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/#organization\"},\"alternateName\":\"IFV Viamed\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/#organization\",\"name\":\"Instituto de fertilidad Viamed\",\"url\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/wp-content\\\/uploads\\\/2022\\\/11\\\/ifv.png\",\"contentUrl\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/wp-content\\\/uploads\\\/2022\\\/11\\\/ifv.png\",\"width\":227,\"height\":61,\"caption\":\"Instituto de fertilidad Viamed\"},\"image\":{\"@id\":\"https:\\\/\\\/www.institutofertilidadviamed.com\\\/hospital-santa-angela-de-la-cruz\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.instagram.com\\\/institutofertilidadviamed\\\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Assisted oocyte activation in Seville - Viamed Fertility Institute","description":"Sperm fragmentation testing is a complementary technique which gives us more diagnostic information about the fertile potential of the male partner.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/assisted-reproduction-techniques\/oocyte-activation-by-calcium-ionophore\/","og_locale":"en_US","og_type":"article","og_title":"Assisted oocyte activation in Seville - Viamed Fertility Institute","og_description":"Sperm fragmentation testing is a complementary technique which gives us more diagnostic information about the fertile potential of the male partner.","og_url":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/assisted-reproduction-techniques\/oocyte-activation-by-calcium-ionophore\/","og_site_name":"Instituto de Fertilidad Viamed - Cl\u00ednica de fertilidad en Sevilla","article_modified_time":"2026-07-13T09:35:42+00:00","og_image":[{"width":2022,"height":1483,"url":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/wp-content\/uploads\/2022\/12\/GettyImages-1189437659.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/assisted-reproduction-techniques\/oocyte-activation-by-calcium-ionophore\/","url":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/assisted-reproduction-techniques\/oocyte-activation-by-calcium-ionophore\/","name":"Assisted oocyte activation in Seville - Viamed Fertility Institute","isPartOf":{"@id":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/assisted-reproduction-techniques\/oocyte-activation-by-calcium-ionophore\/#primaryimage"},"image":{"@id":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/assisted-reproduction-techniques\/oocyte-activation-by-calcium-ionophore\/#primaryimage"},"thumbnailUrl":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/wp-content\/uploads\/2022\/12\/GettyImages-1189437659.jpg","datePublished":"2023-11-17T08:32:23+00:00","dateModified":"2026-07-13T09:35:42+00:00","description":"Sperm fragmentation testing is a complementary technique which gives us more diagnostic information about the fertile potential of the male partner.","breadcrumb":{"@id":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/assisted-reproduction-techniques\/oocyte-activation-by-calcium-ionophore\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/assisted-reproduction-techniques\/oocyte-activation-by-calcium-ionophore\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/assisted-reproduction-techniques\/oocyte-activation-by-calcium-ionophore\/#primaryimage","url":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/wp-content\/uploads\/2022\/12\/GettyImages-1189437659.jpg","contentUrl":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/wp-content\/uploads\/2022\/12\/GettyImages-1189437659.jpg","width":2022,"height":1483,"caption":"Genetic Syndrome and Genetic Disorder, 3D illustration of science concept. Colorful DNA molecule."},{"@type":"BreadcrumbList","@id":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/assisted-reproduction-techniques\/oocyte-activation-by-calcium-ionophore\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Assisted reproduction techniques","item":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/tecnicas-fertilidad\/"},{"@type":"ListItem","position":2,"name":"Assisted oocyte activation in Seville"}]},{"@type":"WebSite","@id":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/#website","url":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/","name":"Instituto de fertilidad Viamed","description":"","publisher":{"@id":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/#organization"},"alternateName":"IFV Viamed","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/#organization","name":"Instituto de fertilidad Viamed","url":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/#\/schema\/logo\/image\/","url":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/wp-content\/uploads\/2022\/11\/ifv.png","contentUrl":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/wp-content\/uploads\/2022\/11\/ifv.png","width":227,"height":61,"caption":"Instituto de fertilidad Viamed"},"image":{"@id":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.instagram.com\/institutofertilidadviamed\/"]}]}},"_links":{"self":[{"href":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/wp-json\/wp\/v2\/pages\/5393","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/wp-json\/wp\/v2\/comments?post=5393"}],"version-history":[{"count":10,"href":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/wp-json\/wp\/v2\/pages\/5393\/revisions"}],"predecessor-version":[{"id":6640,"href":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/wp-json\/wp\/v2\/pages\/5393\/revisions\/6640"}],"up":[{"embeddable":true,"href":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/wp-json\/wp\/v2\/pages\/4074"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/wp-json\/wp\/v2\/media\/3522"}],"wp:attachment":[{"href":"https:\/\/www.institutofertilidadviamed.com\/hospital-santa-angela-de-la-cruz\/en\/wp-json\/wp\/v2\/media?parent=5393"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}