Sperm DNA fragmentation test

The term sperm DNA fragmentation refers to breaks in the genetic material contained in the sperm head. There are two types of fragmentation: single strand breaks and double strand breaks, depending on whether one or both strands of DNA are affected.

If the proportion of fragmented DNA in the sperm is very high, this can have repercussions on male fertility. The integrity of sperm DNA is very important for proper embryonic development after fertilisation.

Implications of sperm DNA fragmentation for male fertility:

Lower fertilisation rate

Poorer embryo quality

Lower embryo implantation rate

Higher miscarriage rate

Sperm fragmentation testing is, therefore, a complementary technique to conventional sperm analysis, which gives us more diagnostic information about the fertile potential of the male partner.

There are many techniques to evaluate sperm fragmentation. At our facility, we use a combined flow cytometry staining protocol, which automatically detects DNA breaks.

Suitable for:

Sterility of unknown origin

Repeat implantation failure

Poor embryo quality

Varicocele

Repeat miscarriage

Men over 45 years old

Male smokers

Seminogram with altered result

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