Repeated implantation failure consists of the failure to achieve a pregnancy after several attempts of assisted reproduction by in vitro fertilisation with good quality embryos.
There is no agreement currently about the number of failed treatments required for a diagnosis of implantation failure due to the multitude of factors that influence it.
However, when there are 2 or 3 embryo transfers with good quality embryos and pregnancy is not achieved, the possibility of an underlying problem may exist.
for which preimplantation genetic diagnosis would be performed if not carried out previously.
a small hole can be made in the outer layer of the embryo so that it can emerge correctly and implant. This is done in many laboratories systematically to all embryos.
in such cases, the endometrium would be studied: its receptivity profile, its microbiota, and possible signs of inflammation.
in these cases, the contribution of donor gametes (eggs or sperm) may be considered.
anatomical, immunological, haematological causes…
These cases require close monitoring and specialised care. At IFV, we have a team of professionals who are experts in the field to solve these difficulties.
Given that the possible causes are varied, in the absence of symptoms that can guide us, we would need to study each and every one of the currently known causes related to implantation failure, which takes time and resources. Therefore, it is important to have the support of other specialities (immunology, haematology, endocrinology, etc…).
Copyright IFV All Rights Reserved
