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Treatments for low response to ovarian stimulation in Seville

At Viamed Fertility Institute, we know that one of the greatest technical and emotional challenges is low response to ovarian stimulation. This is defined as obtaining a reduced number of oocytes after controlled hyperstimulation treatment. This situation is not an “end point”, but a clear sign that your Life Project requires a much more precise and personalised medical strategy.

From Viamed Hospital Santa Ángela de la Cruz, we approach these cases through high-complexity hospital care, understanding that every ovary responds at a different pace and needs a tailored protocol.

What does a low response to medication involve?

It is estimated that between 9% and 25% of patients experience this phenomenon. The impact of obtaining few eggs goes beyond quantity:

Fewer embryos available:

This reduces the cumulative chances of success.

Lower maturation rate:

Often, the few eggs obtained have difficulty completing cytoplasmic maturation.

Risk of cancellation:

Low response often leads to a higher rate of cycle cancellation before puncture.

The aetiology is complex and multifactorial: from natural depletion due to age or advanced endometriosis, to genetic causes, previous surgery or autoimmune factors. That is why, at IFV Sevilla, we do not apply generic solutions.

Advanced treatments: beyond high doses

When facing a low response to ovarian stimulation, the answer is not simply to “give more medication”, but to choose the right strategy. Within the Viamed Salud environment, we offer cutting-edge solutions:

Oocyte accumulation, or DuoStim/vitrification:

We perform two stimulations in the same cycle to maximise egg retrieval before fertilisation.

FSH + LH protocols:

We adjust the hormonal schedule to try to rescue follicles that did not respond in previous cycles.

Adjuvant medication:

We use prior treatments to sensitise ovarian receptors to gonadotrophins.

Mild stimulation and natural cycle:

In certain profiles, gentle stimulation or even a cycle without medication may offer better oocyte quality than massive doses

FAQs: questions about response to stimulation

Unexpected responses can occur due to genetic polymorphisms in hormone receptors. At IFV, we analyse your medical history to adjust the medication in the next attempt.

Yes. The use of long or short protocols, or the addition of LH, can change the way your follicles are recruited and mature.

When the response is low but the quality is acceptable. Vitrifying eggs from 2 or 3 punctures allows us to work in the laboratory with a number of embryos similar to that of a patient with a good response.

Your motherhood deserves an expert view

Do not settle for insufficient results. If you have experienced a low response to ovarian stimulation, come to Hospital Santa Ángela de la Cruz. Let the science and experience of our team in Seville design the definitive plan for your Life Project.

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We are here to support you.
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954 032 022
We are here to support you.
  • Call us
954 032 022

Dr. Pamela Valdivieso Mejía

gynaecologist and specialist in assisted reproduction

  • Specialist in Gynaecology and Obstetrics (MIR programme) at the Virgen de Valme University Hospital.
  • Master's Degree in Human Reproduction from the Universidad Rey Juan Carlos.
  • 11 años de experiencia en reproducción asistida.

Dr. Silvia Valladares Jiménez

Specialist in Endocrinology and Nutrition

  • Specialist in Endocrinology and Nutrition with extensive clinical experience in leading hospitals such as Vall d’Hebron University Hospital and Viamed Santa Ángela de la Cruz Hospital, where she is currently head of department.
  • Her practice focuses on comprehensive patient care, with a particular specialism in reproductive endocrinology, diabetes and endocrine disorders during pregnancy.
  • She has experience in the diagnosis and treatment of conditions such as type 2 diabetes, obesity, thyroid disorders, acromegaly and gynaecomastia, as well as in the management of complex hormonal and metabolic disorders, particularly in female endocrinology.
  • She is actively involved in clinical research, participating in European projects such as EUROCONDOR and PILCHARDUS, as well as contributing to scientific publications and medical conferences. She combines her clinical work with teaching and continuing clinical education.

Dr. José Vilar

GYNAECOLOGIST

Education and Qualifications

  • Medical Degree from the University of Cádiz.
  • Specialist in Obstetrics and Gynaecology, Hospital Universitario Puerta del Mar, Cádiz.

Professional Experience

  • Gynaecologist at IVI Málaga (2013–2018).
  • Gynaecologist at Grupo Internacional UR (2020–2025).
  • Gynaecologist at IFV (2026–present).
  • Consultant in Obstetrics and Gynaecology at the Andalusian Health Service (2019–present).

Qualifications and Awards

  • PhD in Medicine from the University of Cádiz.

Scientific Activity

  • Co-author of several scientific publications in international journals and presentations delivered at national and international conferences.
  • Co-author of several chapters in specialised books on Gynaecology and Assisted Reproduction.

Ángeles Bretón

CLINICAL EMBRYOLOGIST

  • Bachelor's degree in Biotechnology from Pablo de Olavide University
  • Master's degree in Biology and Assisted Human Reproduction Technology from the European University of Madrid.
  • Completion of specialization courses in the assisted reproduction laboratory and workshops on embryo evaluation and selection.
  • Attendance at fertility conferences and seminars on reproductive medicine.

Dr. Carlos Javier Vega Reina

GYNAECOLOGIST

  • Graduated in Medicine from the University of Cádiz.
  • Specialised in Obstetrics and Gynaecology via MIR at the University Hospital of Puerto Real, Cádiz.
  • Master's Degree in Assisted Human Reproduction from the Complutense University of Madrid.

Dr. María Miró

IMMUNOLOGIST

  • Degree in Medicine, University of Cádiz
  • Specialist in Immunology, Reina Sofía University Hospital.
  • Extensive experience in Primary Care Medicine and Hospital Emergency Rooms
  • Reproductive Immunology. Experience in various reproduction centres

Dr. María Eugenia Molina

HEMATOLOGIST

  • Graduate in General Medicine and Surgery. University of Seville.
  • MIR training as a Specialist in Family and Community Medicine. Virgen Macarena University Hospital. Seville.
  • MIR training as a Specialist in Haematology and Haemotherapy. Nuestra Señora de Valme University Hospital. Seville.
  • Specialist in Haematology and Haemotherapy with practice in different health centres in Seville. Consultations on coagulation, myeloproliferative syndromes, red blood cell disorders, chronic and acute lymphoproliferative syndromes;
  • Specialised in disorders associated with recurrent pregnancy loss

Elena Mantrana Bermejo

Gynecologist. Specialist in Reproductive Medicine

  • Degree in Medicine and Surgery from the University of Seville.
  • Specialty in Obstetrics and Gynecology at Hospital Universitario de Valme, Seville.
  • Master’s Degree in Human Reproduction from the Universidad Rey Juan Carlos.
  • Specialist Physician of the Andalusian Health Service in the South Health Management Area (AGSS) of Seville.
  • Coordinator of the Assisted Human Reproduction Unit of the Hospital Universitario de Valme, Seville.
  • Member of the Human Reproduction Advisory Committee of AGSS of Seville.
  • Member of the working group for the update of the Guide for Assisted Human Reproduction of the Ministry of Health of the Andalusian Regional Government.
  • Tutor of Specialist Doctors in Training of the Teaching Area of the University Hospital of Valme.
  • Clinical Tutor Medical Students University of Seville

Alberto Armijo

Gynecologist. Reproductive Medicine Specialist

  • Degree in Medicine and Surgery from Universidad CEU San Pablo de Madrid.
  • Doctor of Medicine from the University of Seville, graduating with highest honours (cum laude)
  • Specialist in Gynecology and Obstetrics via MIR at the Virgen de Valme University Hospital.
  • Master in Human Reproduction, Universidad Complutense de Madrid.
  • Member of the Standing Committee of the Young Interest Group of the Spanish Fertility Society.
  • Clinical Stay. Division of Ultrasound in Obstetrics. Lis Maternity Hospital (Tel Aviv, Israel)